North Rim, Grand Canyon, AZ - 212 miles / 341 kilometers
Take Highway 67 north to Highway 89Alt. Take Highway 89Alt east to Highway 89. Take Highway 89 south to Highway 64. Take Highway 64 west to the East Entrance on the South Rim - known as Desert View.

Flagstaff, AZ - 81 miles / 130 kilometers - there are three ways to go:
* Take I-40 west to Highway 64. Take Highway 64 north directly to the South Rim.
* Take Highway 180 west to Highway 64. Take Highway 64 north directly to the South Rim.
* Take Highway 89 north to Highway 64. Take Highway 64 west to the East Entrance on the South Rim - known as Desert View.

Phoenix, AZ - 231 miles / 372 kilometers
Take I-17 north to I-40. Take I-40 west to Highway 64. Take Highway 64 north directly to the South Rim.

Sedona, AZ - 119 miles / 192 kilometers
Take Highway 89Alt to I-40. Take I-40 west to Highway 64. Take Highway 64 north directly to the South Rim.

Williams, AZ - 63 miles / 101 kilometers
Take Highway 64 north directly to the South Rim.

Las Vegas, NV - 278 miles / 447 kilometers
Take Highway 93 south to I-40. Take I-40 east to Highway 64. Take Highway 64 north directly to the South Rim.

Los Angeles, CA - 494 miles / 795 kilometers
Take I-15 east to I-40. Take I-40 east to Highway 64. Take Highway 64 north directly to the South Rim.

Salt Lake City, UT - 510 miles / 821 kilometers
Take I-15 south to Highway 14. Take Highway 14 east to Highway 89. Take Highway 89 south to Highway 89Alt. Take Highway 89Alt east to Highway 89. Take Highway 89 south to Highway 64. Take Highway 64 west to the East Entrance on the South Rim - known as Desert View.

Denver, CO - 859 miles / 1382 kilometers
Take I-25 south to I-40. Take I-40 west to Highway 64. Take Highway 64 north directly to the South Rim.

Albuquerque, NM - 412 miles / 663 kilometers
Take I-40 west to Highway 64. Take Highway 64 north directly to the South Rim.